Complete maturation does not occur, the expression of co-stimulatory and adhesion molecules and MHC class II is not significantly upregulated, and proinflammatory cytokines are not produced.
Th3 Download As PDFFrom: Encyclopedia of Respiratory Medicine, 2006 Related terms: Interleukin 10 Regulatory T Cell Cytokines CD4 CD8 T Cells CD25 Transforming Growth Factor Beta View all Topics Download as PDF Set alert About this page The Role and Regulation of the Immune Responses Zlatko Dembic, in The Cytokines of the Immune System, 2015 The Role of Th3, and Tr1 Cells The existence of Th3 and Tr1 cells was proven in vitro by generating long-term cell cultures or T-cell cloning, respectively, using differentiation factors such as TGF-, IL-10, IL-4, with anti-IL-12 mAb for Th3 cell culture, and IL-10 and IFN- cytokines for Tr1 cloned lineage.The role for Tr1 effector cells is based on the secreting cytokine profile (IL-10, TGF -) that has an inhibiting effect on proinflammatory Th1 response.
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